Formats
Bruker
MR Solutions
DICOM
NIfTI
MATLAB
01
Load data
DICOM, Bruker, NIfTI, and custom formats.
Import clinical or preclinical DICOM, Bruker, MR Solutions, NIfTI, and custom datasets for DCE-MRI, DSC-MRI, or combined acquisitions.
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Perfusion is a window into tissue function
Start using our software to process your DCE-MRI and DSC-MRI data accurately and precisely. Test out the state-of-the-art algorithms.
Capabilities
Key features
Core tools for importing, processing, modelling, and reviewing quantitative perfusion MRI studies.
Flexible input format
Clinical and preclinical DICOM data from various scanner vendors, Bruker and MR Solutions raw-data format, NIfTI format, and custom formats on request. DCE-MRI, DSC-MRI or simultaneous DCE-DSC-MRI.
Tailored AIF estimation
Pick the AIF that best suits your dataset: choose from our predefined set of AIFs, measure and scale the AIF within an artery, or use our blind-deconvolution estimation technique.
Automation of processing
Automated processing pipelines and intuitive project management facilitate efficient handling of data. Support for batch processing enables scalable execution across multiple datasets.
Regularized parameter estimation
We offer a unique algorithm calculating spatially regularized perfusion-parameter maps to ensure more reliable and spatially coherent results.
Statistical evaluation
Integrated statistical evaluation enables rapid assessment of results, while providing export of full processing data and perfusion maps for your advanced workflows.
Multiple pharmacokinetic models
The software includes all commonly used pharmacokinetic models - Patlak, Tofts, extended Tofts, 2CX, ATH, DCATH, GCTT.
Workflow
How it works
Move from raw dynamic MRI data to quantitative maps with one consistent, reviewable pipeline.
Raw signal
Concentration
02
Convert signal
Signal to contrast-agent concentration.
Transform MRI signal intensity into contrast-agent concentration using T1 maps, T2* maps, or signal-based models.
Population AIFs
03
Configure AIF
Population, arterial, or blind estimation.
Select a predefined population AIF, measure it directly in an artery, or use blind deconvolution for automatic estimation.
PK Models
Patlak
Tofts
Ext. Tofts
2CX
ATH
DCATH
GCTT
04
Estimate parameters
PK models with optional spatial regularization.
Fit established pharmacokinetic models and apply spatial regularization when coherent, robust parameter maps are needed.
Parameter maps
05
Explore and export results
Maps, curves, statistics, and full export.
Review perfusion maps, inspect curves, run integrated statistical analysis, and export complete datasets for downstream workflows.
Applications
Where PerfLab is used
From preclinical MRI labs to oncology centres, PerfLab supports quantitative perfusion analysis wherever model transparency and reproducible outputs matter.
Preclinical oncology
Royal College of Surgeons in Ireland
DCE-MRI perfusion analysis supporting preclinical brain tumour research and treatment response assessment.
Preclinical oncology
Luxembourg Institute of Health
DCE-MRI perfusion analysis of preclinical tumour data acquired after focused-ultrasound heating.
Clinical oncology
Masaryk Memorial Cancer Institute
DCE-MRI perfusion maps for prostate cancer diagnosis and PI-RADS lesion scoring.
Ready to analyse your data?
Email us to request an account for your research.
Request accessFree of charge · Academic & research use
Or write directly to perflab@isibrno.cz · ISI of the CAS, Brno, Czechia
Frequently Asked Questions
Perfusion imaging is a technique that measures microvascular structure and function, such as
fractional blood volume, blood flow, and vessel-wall permeability, valuable mostly in the
diagnosis of oncological and ischemic illnesses.
Contact us at the email address perflab@isibrno.cz. We will create
an account for you and provide you with the necessary information to get started.
Yes, the software is free-of-charge.
No installation is required. PerfLab runs entirely in the browser as a web application, so you only need an internet connection and an account to get started.
The software offers many options, with some of them being automatic. However, the user can also
choose to process the data manually.
Full documentation is available directly within the software for all our users.